Recent Publications

Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity. 2022 Aug 26:S1074-7613(22)00378-8. PMID: 36044899.

Kotas ME, Moore CM, Gurrola JG 2nd, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED. IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function. JCI Insight. 2022 Jul 8;7(13):e159832. PMCID: PMC9310525.

O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 Mar 4;7(69):eabj1080. PMCID: PMC9166270.

Ricardo-Gonzalez RR, Molofsky AB, Locksley RM. ILC2s - development, divergence, dispersal. Curr Opin Immunol. 2022 Apr;75:102168. doi: 10.1016/j.coi.2022.102168. PMCID: PMC9131705.

Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone. Mucosal Immunol. 2021 Nov;14(6):1295-1305. PMCID: PMC8528700.

Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B. A role for IL-33-activated ILC2s in eosinophilic vasculitis. JCI Insight. 2021 Jun 22;6(12):e143366. PMCID: PMC8262498.

Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM. Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. J Exp Med. 2020 Apr 6;217(4):e20191172. PMCID: PMC7144525.

Molofsky AB, Locksley RM. Tissue immunity broadcasts near and far. Nat Rev Immunol. 2020 Feb;20(2):93-94. PMID: 31748703.

Ricardo-Gonzalez RR, Locksley RM. ILC2s chew the fat. J Exp Med. 2019 Sep 2;216(9):1972-1973. PMCID: PMC6719424.

Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity. 2019 Jun 18;50(6):1425-1438.e5. PMCID: PMC6645687.

Schneider C, O'Leary CE, Locksley RM. Regulation of immune responses by tuft cells. Nat Rev Immunol. 2019 Sep;19(9):584-593.PMCID: PMC8331098.

O'Leary CE, Schneider C, Locksley RM. Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry. Annu Rev Immunol. 2019 Apr 26;37:47-72. PMCID: PMC8352721.

Nusse YM*, Savage AK*, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM*, Klein OD*. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 Jul;559(7712):109-113. Erratum in: Nature. 2018 Oct;562(7727):E22. PMC6042247. (*co-authors and co-contributors)

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol. 2018 Oct;19(10):1093-1099. PMCID: PMC6202223.

Van Dyken SJ, Locksley RM. Chitins and chitinase activity in airway diseases. J Allergy Clin Immunol. 2018 Aug;142(2):364-369. PMCID: PMC6078791.

Kotas ME, Locksley RM. Why Innate Lymphoid Cells? Immunity. 2018 Jun 19;48(6):1081-1090. PMCID: PMC6145487.

Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. 2018 Jul 12;174(2):271-284.e14. PMCID: PMC6046262.

Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. Pulmonary neuroendocrine cells amplify allergic asthma responses. Science. 2018 Jun 8;360(6393):eaan8546. PMCID: PMC6387886.

Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 2017 Dec 4;214(12):3627-3643. PMCID: PMC5716040.

Savage AK, Liang HE, Locksley RM. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017 Sep 1;199(5):1912-1922. PMCID: PMC5568484.

Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017 Apr 20;169(3):497-509.e13. PMCID: PMC5444468.

von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 Jan;214(1):27-37. doi: 10.1084/jem.20161274. PMCID: PMC5206504.
 

Additional Publications